News

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Excitation properties of computational models of unmyelinated peripheral axons

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Evoked potentials reveal neural circuits engaged by human deep brain stimulation

Interdisciplinary collaboration led by Steve Schmidt, Ph.D. and former Duke BME Doctoral Student David Brocker working with our long-time collaborator 

Skraps podcast logo - part 2

| Neuromodulation and Bioelectronics w/ Prof. Warren Grill

Neuromodulation and Bioelectronics w/ Prof. Warren Grill Part 2

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Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms

Measurement and analysis of block thresholds and onset responses generated by different kilohertz frequency waveforms and description of underlying mechanisms.

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A comprehensive model-based framework for optimal design of biomimetic patterns of electrical stimulation for prosthetic sensation

Research led by Duke BME Research Scientist Karthik Kumaravelu with extensive collaborations with Lee Miller and 

Neuromodulation and Bioelectronics w/ Warren Grill, Part 1

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Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block

Would not have been possible without contributions from Guosheng Yi, a Post-Doctoral Fellow in the U.S. on a J-1 scholar visa!Open Access!: https://lnkd.in/eywZqYa

lit neurons

| Pratt School of Engineering

Light-Based Deep Brain Stimulation Relieves Symptoms of Parkinson’s Disease

Biomedical engineers at Duke University have used deep brain stimulation based on light to treat motor dysfunction in an animal model of Parkinson’s disease. Succeeding where earlier attempts have failed, the method promises to provide new insights into why deep brain stimulation works and…

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In vivo quantification of excitation and kilohertz frequency block of the rat vagus nerve

Effort lead by Research Director Nikki Pelot

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Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson’s disease

Publication of our latest work exploring feedback signals for closed-loop deep brain stimulation. Steve Schmidt led our effort to quantify "beta bursts" in persons with Parkinson's disease, with and without DBS ...

Poster Award Winner at the 23rd Annual Meeting of the North American Neuromodulation Society in Las Vegas, NV

Congratulations to Nathan Titus, a Duke BME doctoral student in the Grill Lab, and Poster Award Winner at the 23rd Annual Meeting of the North American Neuromodulation Society in Las Vegas, NV.

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Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation

Congratulations Nathan Crosby! His paper on the response of dorsal column axons to kilohertz frequency spinal cord stimulation among the top 10 most cited papers in Journal of Neurophysiology in 2019!

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Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons

Work by Duke BME graduate student Aman Aberra in collaboration with our colleague Angel Peterchev.

MR image of the brain

| Pratt School of Engineering

Evolving Deep Brain Stimulation Patterns

| Duke Research Blog

Deep Brain Stimulation as Treatment for Parkinson’s

As if a Nobel Prize weren’t enough, another Duke scientist recently earned a prestigious award for groundbreaking research. Warren Grill was recognized Nov. 2 at the MDB Trent Semans Center for his research and development of deep brain stimulation (DBS) treatments for Parkinson’s disease.…